Курс: Discipline "Molecular biology" (additional education)

Общее

The discipline is implemented in the autumn and spring semesters of the 2025-2026 academic year. Форум

Seminars for group сФ25-08, сФ24-09 will be dellivered at Rokossovsky st., 1G, 
Lectures for group сФ25-08, сФ24-09 will be dellivered at Kim St., 20 
Department of Fundamental Medicine and Biology - 2nd floor.

Individual consultations and working off

Attendance at lecture

Registration for lecture-type classes is conducted in person at the Department of Fundamental Medicine and Biology in the 2025-2026 academic year.

Materials for lecture-type classes

SEMINAR-TYPE CLASSES

Class 1. Introduction to molecular biology. Main classes of biomolecules. Transformation of energy and information in the cell. The concept of "omics" technologies in medicine.

Nucleic acids: structure and biological functions. Levels of DNA compaction. Methods for studying the structure and functions of nucleic acids.

Class 2. DNA replication and repair: mechanisms and biomedical significance. DNA structure damage and repair mechanisms. Medicine that inhibit replication.

Class 3. Stages of the implementation of genetic information. Structure and functions of different types of RNA. Molecular mechanisms of transcription and translation.

Class 4. Regulation of gene expression in prokaryotes. The theory of the "operon". Mechanisms of gene induction and repression in eukaryotes. Drugs are modulators of gene expression.

Application of molecular genetic technologies in the development and study of medicines. Prospects for gene therapy in the treatment of diseases.

Class 5. Molecular genetic technologies in the development and study of medicines. Prospects of gene therapy in the treatment of diseases. Part 1, 2.

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Class 5. Concluding test on training module No1: "Structure and functions of nucleic acids. Features of the regulation of gene expression in prokaryotes and eukaryotes".

Class 5. Concluding #1

The list of questions Страница

Class 6. Classification and functions of proteins. Methods for studying the structure of proteins. Enzymes in molecular genetic research.

Class 7. Post-translational modifications of protein. Protein folding and its disorders. Molecular mechanisms of proteinopathies. Proteins and enzymes as biomarkers.

Class 8. Principles of coordination of metabolic pathways. Regulation of enzymatic activity. Proteins and enzymes as targets for drugs.

Class 9. Structure and functions of biological membranes. Membrane proteins. Mechanisms of substances transport across the membrane. Intercellular contacts.

Class 10. Receptor function of biological membranes. Principles of receptor signal transmission. Metabotropic and ionotropic receptors.

Class 11. Catalytic receptors. Molecular mechanisms of signal transduction from nuclear and cytoplasmic receptors. Regulation of receptor activity.

Class 12. Concluding test on the training module No2: "Regulation of enzyme activity. Biological membranes. Receptor signal transduction".

The list of questions Страница

Class 13. The cell cycle and its regulation. Phases of mitosis. Proteins and enzymes in the regulation of cell proliferation. Growth factors.

Class 14. Cell damage. Pathobiochemical aspects of necrosis. Types of programmed cell death. The role of apoptosis in health and pathology.

Class 15. Molecular genetic mechanisms of cells tumor transformation and metastasis. Principles of development and study of antitumor drugs.

Class 16. Concluding test on training module No3: "Regulation of cell proliferative activity. Mechanisms of cell death. Oncogenesis".

The list of questions Страница

SPRING SEMESTER

2nd year

Thematic block No. 1. Structure and functions of biological membranes.

Membrane proteins. Mechanisms of substance transport across the membrane. Intercellular contacts.

Thematic block No. 2. Mechanisms of substance transport through the membrane.

Thematic block No. 3. Receptor function of biological membranes.

Receptor signal transduction pathways. Metabotropic and ionotropic receptors.

Thematic block No. 4. Catalytic receptors.

Molecular mechanisms of signal transduction from nuclear and cytoplasmic receptors. Regulation of receptor activity.

Thematic block No. 5. Final control No. 3: "Biological membranes. Receptor signal transduction."

Thematic block No. 6. The cell cycle and its regulation. (Part 1)

Thematic block No. 7. The cell cycle and its regulation. (Part 2)

Thematic block No. 8. Cell damage.

Thematic block No. 9. Cell damage.

Thematic block No. 10. Molecular and genetic mechanisms of tumor cell transformation and metastasis. (Part 1)

Thematic block No. 11. Molecular and genetic mechanisms of tumor cell transformation and metastasis. (Part 2)

Thematic block No. 12. Principles of development and study of antitumor drugs.

Thematic block #13. Final assessment #4: "Regulation of cell proliferative activity. Mechanisms of cell death. Oncogenesis."

Thematic block No. 14. Methods of molecular and cellular biology. (Part 1).

Thematic block No. 15. Methods of molecular and cellular biology. (Part 2).

Thematic block No. 16. Methods of molecular and cellular biology. (Part 3).

Thematic block No. 17. Methods of molecular and cellular biology. (Part 4).

1nd year

Thematic block No. 1. Introduction to molecular biology.

Thematic block No. 2. Nucleic Acids: Structure and Biological Functions. Levels of DNA Compaction. Replication and Repair: Mechanisms and Biomedical Significance.

Thematic block No. 3. Transcription. Translation.

Thematic block No. 4. Regulation of Gene Expression in Prokaryotes and Eukaryotes

Thematic block No. 5. Methods for studying the structure and function of nucleic acids.

Thematic block No. 6. Final assessment 1 "Matrix biosyntheses".

Thematic block No. 7. Classification and Function of Proteins. Mechanisms of Enzymatic Catalysis.

Thematic block No. 8. Principles of coordination of metabolic pathways.

Thematic block No. 9. Post-translational modifications of proteins.

Thematic block No. 10. Methods for determining enzymatic activity.

Thematic block No. 11. Structure and functions of biological membranes.

Thematic block No. 12. Receptor function of biological membranes.

Thematic block No. 13. Final Assessment 2: "Regulation of Enzyme Activity. Biological Membranes. Receptor Signal Transduction."

Thematic block No. 14. Cell cycle and its regulation.

Thematic block No. 15. Cell Damage. The Role of Necrosis and Apoptosis in Health and Disease.

Thematic block No. 16. Molecular genetic mechanisms of tumor cell transformation and metastasis.

Thematic block No. 17. Principles of Development and Study of Anticancer Drugs

Thematic block No. 18. Final Assessment 3: "Regulation of Cell Proliferative Activity. Mechanisms of Cell Death. Oncogenesis."

INDEPENDENT WORK

Assessment tools for ongoing assessment

Timetable of tests, exams, consultations, retakes

Timetable of tests/exams/tests with assessment/pre-examination consultations/retakes Гиперссылка

INTERMEDIATE CERTIFICATION

Assessment tools for certification and the procedure for certification of students Гиперссылка

Тематический план