- Angelin et al., 2017
A. Angelin, L. Gil-de-Gómez, S. Dahiya, J. Jiao, L. Guo, M.H. Levine, Z. Wang, W.J. Quinn, P.K. Kopinski, L. Wang, T. Akimova, Y. Liu, T.R. Bhatti, R. Han, B.L. Laskin, J.A. Baur, I.A. Blair, D.C. Wallace, W.W. Hancock, U.H. BeierFoxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments
- Baixauli et al., 2011
F. Baixauli, N.B. Martín-Cófreces, G. Morlino, Y.R. Carrasco, C. Calabia-Linares, E. Veiga, J.M. Serrador, F. Sánchez-MadridThe mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse
- Baixauli et al., 2015
F. Baixauli, R. Acin-Perez, C. Villarroya-Beltri, C. Mazzeo, N. Nunez-Andrade, E. Gabande-Rodriguez, M.D. Ledesma, A. Blazquez, M.A. Martin, J.M. Falcon-Perez, J.M. Redondo, J.A. Enriquez, M. MittelbrunnMitochondrial respiration controls lysosomal function during inflammatory T cell responses
- Ballesteros-Tato et al., 2016
A. Ballesteros-Tato, T.D. Randall, F.E. Lund, R. Spolski, W.J. Leonard, B. LeónT follicular helper cell plasticity shapes pathogenic T helper 2 cell-mediated immunity to inhaled house dust mite
- Balmer et al., 2016
M.L. Balmer, E.H. Ma, G.R. Bantug, J. Grählert, S. Pfister, T. Glatter, A. Jauch, S. Dimeloe, E. Slack, P. Dehio, M.A. Krzyzaniak, C.G. King, A.-V. Burgener, M. Fischer, L. Develioglu, R. Belle, M. Recher, W.V. Bonilla, A.J. Macpherson, S. Hapfelmeier, R.G. Jones, C. HessMemory CD8 + T cells require increased concentrations of acetate induced by stress for optimal function
- Bantug et al., 2017
G.R. Bantug, L. Galluzzi, G. Kroemer, C. HessThe spectrum of T cell metabolism in health and disease
- Bengsch et al., 2016
B. Bengsch, A.L. Johnson, M. Kurachi, P.M. Odorizzi, K.E. Pauken, J. Attanasio, E. Stelekati, L.M. McLane, M.A. Paley, G.M. Delgoffe, E.J. WherryBioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8 + T cell exhaustion
- Birsoy et al., 2015
K. Birsoy, T. Wang, W.W. Chen, E. Freinkman, M. Abu-Remaileh, D.M. SabatiniAn essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
- Buck et al., 2016
M.D. Buck, D.O. Sullivan, R.I. Klein, T.B. Huber, A.S. Rambold, E.L. Pearce, R.I. Klein Geltink, J.D. Curtis, C.-H. Chang, D.E. Sanin, J. Qiu, O. Kretz, D. Braas, G.J.W. Van Der Windt, Q. Chen, S. Ching, -Cheng Huang, C.M. O'neill, B.T. Edelson, E.J. Pearce, H. SesakiMitochondrial dynamics controls T cell fate through metabolic programming correspondence mitochondrial dynamics controls T cell fate through metabolic programming
- Burté et al., 2014
F. Burté, V. Carelli, P.F. Chinnery, P. Yu-Wai-ManDisturbed mitochondrial dynamics and neurodegenerative disorders
- Campello and Scorrano, 2010
S. Campello, L. ScorranoMitochondrial shape changes: orchestrating cell pathophysiology
- Campello et al., 2006
S. Campello, R.A. Lacalle, M. Bettella, S. Mañes, L. Scorrano, A. ViolaOrchestration of lymphocyte chemotaxis by mitochondrial dynamics
J. Exp. Med., 203 (2006)
- Carr et al., 2010
E.L. Carr, A. Kelman, G.S. Wu, R. Gopaul, E. Senkevitch, A. Aghvanyan, A.M. Turay, K.A. FrauwirthGlutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
- Chang et al., 2013
C.-H. Chang, J.D. Curtis, L.B. Maggi, B. Faubert, A.V. Villarino, D.O. Sullivan, S. Ching, -Cheng Huang, G.J.W. Van Der Windt, J. Blagih, J. Qiu, J.D. Weber, E.J. Pearce, R.G. Jones, E.L. PearcePosttranscriptional control of T cell effector function by aerobic glycolysis
- Chou et al., 2014
C. Chou, A.K. Pinto, J.D. Curtis, S.P. Persaud, M. Cella, C.-C. Lin, B.T. Edelson, P.M. Allen, M. Colonna, E.L. Pearce, M.S. Diamond, T. EgawaC-Myc-induced transcription factor AP4 is required for host protection mediated by CD8 + T cells
- Christie et al., 2012
D.A. Christie, P. Mitsopoulos, J. Blagih, S.D. Dunn, J. St-Pierre, R.G. Jones, G.M. Hatch, J. MadrenasStomatin-like protein 2 deficiency in T cells is associated with altered mitochondrial respiration and defective CD4 + T cell responses
J. Immunol., 189 (2012)
- D'Souza et al., 2007
A.D. D'Souza, N. Parikh, S.M. Kaech, G.S. ShadelConvergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation
- Dang et al., 2011
E.E.V. Dang, J. Barbi, H.-Y. Yang, D. Jinasena, H. Yu, Y. Zheng, Z. Bordman, J. Fu, Y. Kim, H.-R. Yen, W. Luo, K. Zeller, L. Shimoda, S.S.L. Topalian, G.G.L. Semenza, C.C.V. Dang, D.D.M. Pardoll, F. PanControl of TH17/Treg balance by hypoxia-inducible factor 1
- Daniele and Schiaffino, 2014
T. Daniele, M.V. SchiaffinoOrganelle biogenesis and interorganellar connections: better in contact than in isolation
Commun. Integr. Biol., 7 (2014)
e29587-1-e29587-6
- Demers-Lamarche et al., 2016
J. Demers-Lamarche, G. Guillebaud, M. Tlili, K. Todkar, N. Bélanger, M. Grondin, A.P. Nguyen, J. Michel, M. GermainLoss of mitochondrial function impairs lysosomes
J. Biol. Chem. (2016)
jbc.M115.695825
- Diebold and Chandel, 2016
L. Diebold, N.S. ChandelMitochondrial ROS regulation of proliferating cells
- Dimeloe et al., 2016
S. Dimeloe, M. Mehling, C. Frick, J. Loeliger, G.R. Bantug, U. Sauder, M. Fischer, R. Belle, L. Develioglu, S. Tay, A. Langenkamp, C. HessThe immune-metabolic basis of effector memory CD4 + T cell function under hypoxic conditions
- Dimeloe et al., 2017
S. Dimeloe, A.V. Burgener, J. Gr??hlert, C. HessT-cell metabolism governing activation, proliferation and differentiation; a modular view
- Drose and Brandt, 2012
S. Drose, U. BrandtMolecular mechanisms of superoxide production by the mitochondrial respiratory chain
- Eleftheriadis et al., 2015
T. Eleftheriadis, G. Pissas, G. Antoniadi, V. Liakopoulos, I. StefanidisMalate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells
- Farber et al., 2013
D.L. Farber, N.A. Yudanin, N.P. RestifoHuman memory T cells: generation, compartmentalization and homeostasis
- Filadi et al., 2017
R. Filadi, P. Theurey, P. PizzoThe endoplasmic reticulum-mitochondria coupling in health and disease: molecules, functions and significance
- Förster et al., 2008
R. Förster, A.C. Davalos-Misslitz, A. RotCCR7 and its ligands: balancing immunity and tolerance
- Geiger et al., 2016
R. Geiger, J.C. Rieckmann, T. Wolf, C. Basso, Y. Feng, T. Fuhrer, M. Kogadeeva, P. Picotti, F. Meissner, M. Mann, N. Zamboni, F. Sallusto, A. LanzavecchiaL-arginine modulates T cell metabolism and enhances survival and anti-tumor activity
- Giorgi et al., 2015
C. Giorgi, S. Missiroli, S. Patergnani, J. Duszynski, M.R. Wieckowski, P. PintonMitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implications
- Gubin et al., 2014
M.M. Gubin, X. Zhang, H. Schuster, E. Caron, J.P. Ward, T. Noguchi, Y. Ivanova, J. Hundal, C.D. Arthur, W.-J. Krebber, G.E. Mulder, M. Toebes, M.D. Vesely, S.S.K. Lam, A.J. Korman, J.P. Allison, G.J. Freeman, A.H. Sharpe, E.L. Pearce, T.N. Schumacher, R. Aebersold, H.-G. Rammensee, C.J.M. Melief, E.R. Mardis, W.E. Gillanders, M.N. Artyomov, R.D. SchreiberCheckpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
- Halstead et al., 2015
J.M. Halstead, T. Lionnet, J.H. Wilbertz, F. Wippich, A. Ephrussi, R.H. Singer, J.A. ChaoTranslation. An RNA biosensor for imaging the first round of translation from single cells to living animals
- Hansson et al., 2004
A. Hansson, N. Hance, E. Dufour, A. Rantanen, K. Hultenby, D.A. Clayton, R. WibomA Switch in Metabolism Precedes Increased Mitochondrial Biogenesis in Respiratory Chain-deficient Mouse Hearts
101 (2004)
- Helle et al., 2013
S.C.J. Helle, G. Kanfer, K. Kolar, A. Lang, A.H. Michel, B. KornmannOrganization and function of membrane contact sites
- Ho et al., 2015
P.-C. Ho, J.D. Bihuniak, A.N. Macintyre, M. Staron, X. Liu, R. Amezquita, Y.-C. Tsui, G. Cui, G. Micevic, J.C. Perales, S.H. Kleinstein, E.D. Abel, K.L. Insogna, S. Feske, J.W. Locasale, M.W. Bosenberg, J.C. Rathmell, S.M. KaechPhosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
- Jha et al., 2015
A.K. Jha, S.C.-C. Huang, A. Sergushichev, V. Lampropoulou, Y. Ivanova, E. Loginicheva, K. Chmielewski, K.M. Stewart, J. Ashall, B. Everts, E.J. Pearce, E.M. Driggers, M.N. ArtyomovNetwork integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
- Johnson and Rathmell, 2016
M.O. Johnson, J.C. RathmellAIF is “always in fashion” for T cells
- Kaminski et al., 2010
M.M. Kaminski, S.W. Sauer, C.-D. Klemke, D. Suss, J.G. Okun, P.H. Krammer, K. GulowMitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression
- Kamiński et al., 2012
M.M. Kamiński, S.W. Sauer, M. Kamiński, S. Opp, T. Ruppert, P. Grigaravičius, P. Grudnik, H.-J. Gröne, P.H. Krammer, K. GülowT cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation
- Karmaus and Chi, 2014
P.W.F. Karmaus, H. Chic-Myc and AP4: a relay team for metabolic reprogramming of CD8 + T cells
- Klysz et al., 2015
D. Klysz, X. Tai, P.A. Robert, M. Craveiro, G. Cretenet, L. Oburoglu, C. Mongellaz, S. Floess, V. Fritz, M.I. Matias, C. Yong, N. Surh, J.C. Marie, J. Huehn, V. Zimmermann, S. Kinet, V. Dardalhon, N. TaylorGlutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Sci. Signal., 8 (2015)
- La Rovere et al., 2016
R.M.L. La Rovere, G. Roest, G. Bultynck, J.B. ParysIntracellular Ca(2 +) signaling and Ca(2 +) microdomains in the control of cell survival, apoptosis and autophagy
- Lambert and Brand, 2009
A.J. Lambert, M.D. BrandReactive oxygen species production by mitochondria
- Lewis, 2001
R.S. LewisCalcium Signaling Mechanisms in T Lymphocytes
- Li et al., 2014
T. Li, M. Liu, X. Feng, Z. Wang, I. Das, Y. Xu, X. Zhou, Y. Sun, K.-L. Guan, Y. Xiong, Q.-Y. LeiGlyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal
- Liesa and Shirihai, 2016
M. Liesa, O.S. ShirihaiMitochondrial networking in T cell memory
- Magombedze et al., 2013
G. Magombedze, P.B.J. Reddy, S. Eda, V.V. GanusovCellular and population plasticity of helper CD4 + T cell responses
- Mak et al., 2017
T.W. Mak, M. Grusdat, G.S. Duncan, C. Dostert, Y. Nonnenmacher, M. Cox, C. Binsfeld, Z. Hao, A. Brüstle, M. Itsumi, C. Jäger, Y. Chen, O. Pinkenburg, B. Camara, M. Ollert, C. Bindslev-Jensen, V. Vasiliou, C. Gorrini, P.A. Lang, M. Lohoff, I.S. Harris, K. Hiller, D. BrennerGlutathione primes T cell metabolism for inflammation
- Mendoza et al., 2017
A. Mendoza, V. Fang, C. Chen, M. Serasinghe, A. Verma, J. Muller, V.S. Chaluvadi, M.L. Dustin, T. Hla, O. Elemento, J.E. Chipuk, S.R. SchwabLymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells
- Michalek et al., 2011
R.D. Michalek, V.A. Gerriets, S.R. Jacobs, A.N. Macintyre, N.J. MacIver, E.F. Mason, S.A. Sullivan, A.G. Nichols, J.C. RathmellCutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4 + T cell subsets
J. Immunol., 186 (2011)
- Milasta et al., 2016
S. Milasta, C.P. Dillon, O.E. Sturm, K.C. Verbist, T.L. Brewer, G. Quarato, S.A. Brown, S. Frase, L.J. Janke, S.S. Perry, P.G. Thomas, D.R. GreenApoptosis-inducing-factor-dependent mitochondrial function is required for T cell but not B cell function
- Morlino et al., 2014
G. Morlino, O. Barreiro, F. Baixauli, J. Robles-Valero, J.M. González-Granado, R. Villa-Bellosta, J. Cuenca, C.O. Sánchez-Sorzano, E. Veiga, N.B. Martín-Cófreces, F. Sánchez-MadridMiro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity
- Murphy and Stockinger, 2010
K.M. Murphy, B. StockingerEffector T cell plasticity: flexibility in the face of changing circumstances
- Newsholme et al., 1986
P. Newsholme, R. Curi, S. Gordon, E.A. NewsholmeMetabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
Biochem. J., 239 (1986), pp. 121-125
- O'Neill and Hardie, 2013
L.A.J. O'Neill, D.G. HardieMetabolism of inflammation limited by AMPK and pseudo-starvation
- O'Shea and Paul, 2010
J.J. O'Shea, W.E. PaulMechanisms underlying lineage commitment and plasticity of helper CD4 + T cells
- Omilusik et al., 2013
K.D. Omilusik, L.L. Nohara, S. Stanwood, W.A. JefferiesWeft, warp, and weave: the intricate tapestry of calcium channels regulating T lymphocyte function
- Pearce et al., 2009
E.L. Pearce, M.C. Walsh, P.J. Cejas, G.M. Harms, H. Shen, L.-S. Wang, R.G. Jones, Y. ChoiEnhancing CD8 T-cell memory by modulating fatty acid metabolism
- Peng et al., 2016
M. Peng, N. Yin, S. Chhangawala, K. Xu, C.S. Leslie, M.O. LiAerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
- Phillips et al., 2001
J.L. Phillips, S.W. Hayward, Y. Wang, J. Vasselli, C. Pavlovich, H. Padilla-Nash, J.R. Pezullo, B.M. Ghadimi, G.D. Grossfeld, A. Rivera, W.M. Linehan, G.R. Cunha, T. RiedThe consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis
- Procaccini et al., 2016
C. Procaccini, F. Carbone, D. Di Silvestre, F. Brambilla, V. De Rosa, M. Galgani, D. Faicchia, G. Marone, D. Tramontano, M. Corona, C. Alviggi, A. Porcellini, A. La Cava, P. Mauri, G. MatareseThe proteomic landscape of human ex vivo regulatory and conventional T cells reveals specific metabolic requirements
- Quintana et al., 2011
A. Quintana, M. Pasche, C. Junker, D. Al-Ansary, H. Rieger, C. Kummerow, L. Nunez, C. Villalobos, P. Meraner, U. Becherer, J. Rettig, B.A. Niemeyer, M. HothCalcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation
- Rhoads et al., 2017
J.P. Rhoads, A.S. Major, J.C. RathmellFine tuning of immunometabolism for the treatment of rheumatic diseases
- Ron-Harel et al., 2016
N. Ron-Harel, D. Santos, J.M. Ghergurovich, P.T. Sage, A. Reddy, S.B. Lovitch, N. Dephoure, F.K. Satterstrom, M. Sheffer, J.B. Spinelli, S. Gygi, J.D. Rabinowitz, A.H. Sharpe, M.C. HaigisMitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation
- Sánchez-Madrid and Serrador, 2009
F. Sánchez-Madrid, J.M. SerradorBringing up the rear: defining the roles of the uropod
- Scharping et al., 2016
N.E. Scharping, A.V. Menk, R.S. Moreci, R.D. Whetstone, R.E. Dadey, S.C. Watkins, R.L. Ferris, G.M. DelgoffeThe tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
- Sena et al., 2013
L.A. Sena, S. Li, A. Jairaman, M. Prakriya, T. Ezponda, D.A. Hildeman, C.-R. Wang, P.T. Schumacker, J.D. Licht, H. Perlman, P.J. Bryce, N.S. ChandelMitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
- Shi et al., 2011
L.Z. Shi, R. Wang, G. Huang, P. Vogel, G. Neale, D.R. Green, H. ChiHIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of Th 17 and T reg cells
- Sukumar et al., 2016
M. Sukumar, J. Liu, G.U. Mehta, S.J. Patel, R. Roychoudhuri, J.G. Crompton, C.A. Klebanoff, Y. Ji, P. Li, Z. Yu, G.D. Whitehill, D. Clever, R.L. Eil, D.C. Palmer, S. Mitra, M. Rao, K. Keyvanfar, D.S. Schrump, E. Wang, F.M. Marincola, L. Gattinoni, W.J. Leonard, P. Muranski, T. Finkel, N.P. RestifoMitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy
- Sullivan et al., 2015
L.B. Sullivan, D.Y. Gui, A.M. Hosios, L.N. Bush, E. Freinkman, M.G. Vander HeidenSupporting aspartate biosynthesis is an essential function of respiration in proliferating cells
- Tan et al., 2017
H. Tan, K. Yang, Y. Li, T.I. Shaw, Y. Wang, D.B. Blanco, X. Wang, J.-H. Cho, H. Wang, S. Rankin, C. Guy, J. Peng, H. ChiIntegrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation
- Vander Heiden et al., 2009
M.G. Vander Heiden, L.C. Cantley, C.B. ThompsonUnderstanding the Warburg effect: the metabolic requirements of cell proliferation
- Vernochet et al., 2012
C. Vernochet, A. Mourier, O. Bezy, Y. MacOtela, J. Boucher, M.J. Rardin, D. An, K.Y. Lee, O.R. Ilkayeva, C.M. Zingaretti, B. Emanuelli, G. Smyth, S. Cinti, C.B. Newgard, B.W. Gibson, N.G. Larsson, C.R. KahnAdipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance
- Wang et al., 2001
J. Wang, J.C. Lo, A. Foster, P. Yu, H.M. Chen, Y. Wang, K. Tamada, L. Chen, Y.X. FuThe regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT
- Wang et al., 2011
R. Wang, C.P. Dillon, L.Z. Shi, S. Milasta, R. Carter, D. Finkelstein, L.L. McCormick, P. Fitzgerald, H. Chi, J. Munger, D.R. GreenThe transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
- Williams and Bevan, 2007
M.A. Williams, M.J. BevanEffector and memory CTL differentiation
- van der Windt et al., 2012
G.J.W. van der Windt, B. Everts, C.-H. Chang, J.D. Curtis, T.C. Freitas, E. Amiel, E.J. Pearce, E.L. PearceMitochondrial respiratory capacity is a critical regulator of CD8 + T cell memory development
- van der Windt et al., 2013
G.J.W. van der Windt, D. O'Sullivan, B. Everts, S.C.-C. Huang, M.D. Buck, J.D. Curtis, C.-H. Chang, A.M. Smith, T. Ai, B. Faubert, R.G. Jones, E.J. Pearce, E.L. PearceCD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
- Wolf and Guse, 2017
I.M.A. Wolf, A.H. GuseCa(2 +) microdomains in T-lymphocytes
- Wu et al., 2017
C. Wu, Z. Chen, V. Dardalhon, S. Xiao, T. Thalhamer, M. Liao, A. Madi, R.F. Franca, T. Han, M. Oukka, V. KuchrooThe transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program HHS Public Access
- Zhu et al., 2010
J. Zhu, H. Yamane, W.E. PaulDifferentiation of effector CD4 T cell populations