Ashraf J. M., Ahmad S., Choi I., Ahmad N., Farhan M., Tatyana G., et al. . (2015). Recent advances in detection of AGEs: immunochemical, bioanalytical and biochemical approaches. IUBMB Life 67, 897–913. 10.1002/iub.1450 - DOI - PubMed
Aso Y., Inukai T., Tayama K., Takemura Y. (2000). Serum concentrations of advanced glycation endproducts are associated with the development of atherosclerosis as well as diabetic microangiopathy in patients with type 2 diabetes. Acta Diabetol. 37, 87–92. 10.1007/s005920070025 - DOI - PubMed
Baig M. H., Jan A. T., Rabbani G., Ahmad K., Ashraf J. M., Kim T., et al. . (2017). Methylglyoxal and advanced glycation end products: insight of the regulatory machinery affecting the myogenic program and of its modulation by natural compounds. Sci. Rep. 7:5916. 10.1038/s41598-017-06067-5 - DOI - PMC - PubMed
Baulmann J., Nurnberger J., Slany J., Schmieder R., Schmidt-Trucksass A., Baumgart D., et al. (2010). [Arterial stiffness and pulse wave analysis]. Dtsch. Med. Wochenschr. 135(Suppl. 1), S4–S14. 10.1055/s-0030-1249183 - DOI - PubMed
Brouwers O., Niessen P. M., Ferreira I., Miyata T., Scheffer P. G., Teerlink T., et al. . (2011). Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats. J. Biol. Chem. 286, 1374–1380. 10.1074/jbc.M110.144097 - DOI - PMC - PubMed
Brouwers O., Niessen P. M., Miyata T., Ostergaard J. A., Flyvbjerg A., Peutz-Kootstra C. J., et al. . (2014). Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes. Diabetologia 57, 224–235. 10.1007/s00125-013-3088-5 - DOI - PubMed
Bucciarelli L. G., Wendt T., Qu W., Lu Y., Lalla E., Rong L. L., et al. . (2002). RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice. Circulation 106, 2827–2835. 10.1161/01.CIR.0000039325.03698.36 - DOI - PubMed
Cai W., Gao Q.-D., Zhu L., Peppa M., He C., Vlassara H. (2002). Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction. Mol. Med. 8, 337–346. - PMC - PubMed
Campbell D. J., Somaratne J. B., Jenkins A. J., Prior D. L., Yii M., Kenny J. F., et al. . (2011). Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease. Cardiovasc. Diabetol. 10, 80–80. 10.1186/1475-2840-10-80 - DOI - PMC - PubMed
Campbell D. J., Somaratne J. B., Jenkins A. J., Prior D. L., Yii M., Kenny J. F., et al. . (2012). Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels. PLoS ONE 7:e49813. 10.1371/journal.pone.0049813 - DOI - PMC - PubMed
Chang J. S., Wendt T., Qu W., Kong L., Zou Y. S., Schmidt A. M., et al. . (2008). Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 102, 905–913. 10.1161/CIRCRESAHA.107.165308 - DOI - PubMed
Chavakis T., Bierhaus A., Nawroth P. P. (2004). RAGE (receptor for advanced glycation end products): a central player in the inflammatory response. Microb. Infect. 6, 1219–1225. 10.1016/j.micinf.2004.08.004 - DOI - PubMed
Choi K. M., Yoo H. J., Kim H. Y., Lee K. W., Seo J. A., Kim S. G., et al. . (2009). Association between endogenous secretory RAGE, inflammatory markers and arterial stiffness. Int. J. Cardiol. 132, 96–101. 10.1016/j.ijcard.2007.10.047 - DOI - PubMed
Daffu G., del Pozo C. H., O'Shea K. M., Ananthakrishnan R., Ramasamy R., Schmidt A. M. (2013). Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond. Int. J. Mol. Sci. 14, 19891–19910. 10.3390/ijms141019891 - DOI - PMC - PubMed
Da Moura Semedo C., Webb M., Waller H., Khunti K., Davies M. (2017). Skin autofluorescence, a non-invasive marker of advanced glycation end products: clinical relevance and limitations. Postgrad. Med. J. 93, 289–294. 10.1136/postgradmedj-2016-134579 - DOI - PubMed
Forbes J. M., Yee L. T., Thallas V., Lassila M., Candido R., Jandeleit-Dahm K. A., et al. . (2004). Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis. Diabetes 53, 1813–1823. 10.2337/diabetes.53.7.1813 - DOI - PubMed
Gaballa M. A., Jacob C. T., Raya T. E., Liu J., Simon B., Goldman S. (1998). Large artery remodeling during aging: biaxial passive and active stiffness. Hypertension 32, 437–443. 10.1161/01.HYP.32.3.437 - DOI - PubMed
Gao X., Zhang H., Schmidt A. M., Zhang C. (2008). AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice. Am. J. Physiol. Heart Circ. Physiol. 295, H491–H498. 10.1152/ajpheart.00464.2008 - DOI - PMC - PubMed
Giacco F., Du X., D'Agati V. D., Milne R., Sui G., Geoffrion M., et al. . (2014). Knockdown of glyoxalase 1 mimics diabetic nephropathy in nondiabetic mice. Diabetes 63, 291–299. 10.2337/db13-0316 - DOI - PMC - PubMed
Goldin A., Beckman J. A., Schmidt A. M., Creager M. A. (2006). Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 114, 597–605. 10.1161/CIRCULATIONAHA.106.621854 - DOI - PubMed
Greenwald S. E. (2007). Ageing of the conduit arteries. J. Pathol. 211, 157–172. 10.1002/path.2101 - DOI - PubMed
Gu Q., Wang B., Zhang X. F., Ma Y. P., Liu J. D., Wang X. Z. (2014). Contribution of receptor for advanced glycation end products to vasculature-protecting effects of exercise training in aged rats. Eur. J. Pharmacol. 741, 186–194. 10.1016/j.ejphar.2014.08.017 - DOI - PubMed
Hadi H. A. R., Suwaidi J. A. (2007). Endothelial dysfunction in diabetes mellitus. Vasc. Health Risk Manag. 3, 853–876. - PMC - PubMed
Hallam K. M., Li Q., Ananthakrishnan R., Kalea A., Zou Y. S., Vedantham S., et al. . (2010). Aldose reductase and AGE–RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats. Aging Cell 9, 776–784. 10.1111/j.1474-9726.2010.00606.x - DOI - PMC - PubMed
Hanford L. E., Enghild J. J., Valnickova Z., Petersen S. V., Schaefer L. M., Schaefer T. M., et al. . (2004). Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE). J. Biol. Chem. 279, 50019–50024. 10.1074/jbc.M409782200 - DOI - PMC - PubMed
He C., Sabol J., Mitsuhashi T., Vlassara H. (1999). Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration. Diabetes 48, 1308–1315. 10.2337/diabetes.48.6.1308 - DOI - PubMed
Henning C., Glomb M. A. (2016). Pathways of the Maillard reaction under physiological conditions. Glycoconj. J. 33, 499–512. 10.1007/s10719-016-9694-y - DOI - PubMed
Herold K., Moser B., Chen Y., Zeng S., Yan S. F., Ramasamy R., et al. . (2007). Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress. J. Leukoc. Biol. 82, 204–212. 10.1189/jlb.1206751 - DOI - PubMed
Hudson B. I., Kalea A. Z., Del Mar Arriero M., Harja E., Boulanger E., D'Agati V., et al. . (2008). Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42. J. Biol. Chem. 283, 34457–34468. 10.1074/jbc.M801465200 - DOI - PMC - PubMed
Izzo J. L., Jr. (2004). Arterial stiffness and the systolic hypertension syndrome. Curr. Opin. Cardiol. 19, 341–352. 10.1097/01.hco.0000126581.89648.10 - DOI - PubMed
Jo-Watanabe A., Ohse T., Nishimatsu H., Takahashi M., Ikeda Y., Wada T., et al. . (2014). Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation. Aging Cell 13, 519–528. 10.1111/acel.12204 - DOI - PMC - PubMed
Kaess B. M., Rong J., Larson M. G., Hamburg N. M., Vita J. A., Levy D., et al. . (2012). Aortic stiffness, blood pressure progression, and incident hypertension. JAMA 308, 875–881. 10.1001/2012.jama.10503 - DOI - PMC - PubMed
Kalea A. Z., Reiniger N., Yang H., Arriero M., Schmidt A. M., Hudson B. I. (2009). Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene. FASEB J. 23, 1766–1774. 10.1096/fj.08-117739 - DOI - PMC - PubMed
Kass D. A., Shapiro E. P., Kawaguchi M., Capriotti A. R., Scuteri A., deGroof R. C., et al. . (2001). Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation 104, 1464–1470. 10.1161/hc3801.097806 - DOI - PubMed
Kay A. M., Simpson C. L., Stewart J. A. (2016). The role of AGE/RAGE signaling in diabetes-mediated vascular calcification. J. Diabetes Res. 2016:6809703. 10.1155/2016/6809703 - DOI - PMC - PubMed
Kislinger T., Tanji N., Wendt T., Qu W., Lu Y., Ferran L. J., Jr., et al. . (2001). Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice. Arterioscler. Thromb. Vasc. Biol. 21, 905–910. 10.1161/01.ATV.21.6.905 - DOI - PubMed
Koch M., Chitayat S., Dattilo B. M., Schiefner A., Diez J., Chazin W. J., et al. . (2010). Structural basis for ligand recognition and activation of RAGE. Structure 18, 1342–1352. 10.1016/j.str.2010.05.017 - DOI - PMC - PubMed
Lakatta E. G., Levy D. (2003). Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a “set up” for vascular disease. Circulation 107, 139–146. 10.1161/01.CIR.0000048892.83521.58 - DOI - PubMed
Lakatta E. G., Sollott S. J. (2002). Perspectives on mammalian cardiovascular aging: humans to molecules. Comp. Biochem. Physiol. Part A Mol. Integr. Physiol. 132, 699–721. 10.1016/S1095-6433(02)00124-1 - DOI - PubMed
Laurent S., Boutouyrie P., Asmar R., Gautier I., Laloux B., Guize L., et al. . (2001). Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37, 1236–1241. 10.1161/01.HYP.37.5.1236 - DOI - PubMed
Li H., Horke S., Förstermann U. (2014). Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis 237, 208–219. 10.1016/j.atherosclerosis.2014.09.001 - DOI - PubMed
Luevano-Contreras C., Chapman-Novakofski K. (2010). Dietary advanced glycation end products and aging. Nutrients 2, 1247–1265. 10.3390/nu2121247 - DOI - PMC - PubMed
Lutgers H. L., Gerrits E. G., Graaff R., Links T. P., Sluiter W. J., Gans R. O., et al. . (2009). Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus. Diabetologia 52, 789–797. 10.1007/s00125-009-1308-9 - DOI - PubMed
Manigrasso M. B., Pan J., Rai V., Zhang J., Reverdatto S., Quadri N., et al. . (2016). Small molecule inhibition of ligand-stimulated RAGE-DIAPH1 signal transduction. Sci. Rep. 6:22450. 10.1038/srep22450 - DOI - PMC - PubMed
Mattace-Raso F. U., van der Cammen T. J., Hofman A., van Popele N. M., Bos M. L., Schalekamp M. A., et al. . (2006). Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113, 657–663. 10.1161/CIRCULATIONAHA.105.555235 - DOI - PubMed
McNulty M., Mahmud A., Feely J. (2007). Advanced glycation end-products and arterial stiffness in hypertension. Am. J. Hypertens. 20, 242–247. 10.1016/j.amjhyper.2006.08.009 - DOI - PubMed
Meerwaldt R., Graaff R., Oomen P. H. N., Links T. P., Jager J. J., Alderson N. L., et al. . (2004). Simple non-invasive assessment of advanced glycation endproduct accumulation. Diabetologia 47, 1324–1330. 10.1007/s00125-004-1451-2 - DOI - PubMed
Montezano A. C., Touyz R. M. (2014). Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research. Antioxid. Redox Signal. 20, 164–182. 10.1089/ars.2013.5302 - DOI - PMC - PubMed
Mozaffarian D., Benjamin E. J., Go A. S., Arnett D. K., Blaha M. J., Cushman M., et al. (2016). Executive summary: heart disease and stroke statistics−2016 update: a report from the american heart association. Circulation 133, 447–454. 10.1161/CIR.0000000000000366 - DOI - PubMed
Münch G., Keis R., Wessels A., Riederer P., Bahner U., Heidland A., et al. . (1997). Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA. Eur. J. Clin. Chem. Clin. Biochem. 35, 669–677. 10.1515/cclm.1997.35.9.669 - DOI - PubMed
Najjar S. S., Scuteri A., Lakatta E. G. (2005). Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 46, 454–462. 10.1161/01.HYP.0000177474.06749.98 - DOI - PubMed
Noordzij M. J., Lefrandt J. D., Loeffen E. A., Saleem B. R., Meerwaldt R., Lutgers H. L., et al. . (2012). Skin autofluorescence is increased in patients with carotid artery stenosis and peripheral artery disease. Int. J. Cardiovasc. Imaging 28, 431–438. 10.1007/s10554-011-9805-6 - DOI - PMC - PubMed
Park L., Raman K. G., Lee K. J., Lu Y., Ferran L. J., Jr., Chow W. S., et al. . (1998). Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat. Med. 4, 1025–1031. 10.1038/2012 - DOI - PubMed
Pepe S., Lakatta E. G. (2005). Aging hearts and vessels: masters of adaptation and survival. Cardiovasc. Res. 66, 190–193. 10.1016/j.cardiores.2005.03.004 - DOI - PubMed
Peppa M., Raptis S. A. (2008). Advanced glycation end products and cardiovascular disease. Curr. Diabetes Rev. 4, 92–100. 10.2174/157339908784220732 - DOI - PubMed
Pitt J. J. (2009). Principles and applications of liquid chromatography-mass spectrometry in clinical biochemistry. Clin. Biochem. Rev. 30, 19–34. - PMC - PubMed
Rabbani N., Thornalley P. J. (2014). The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy. Diabetes 63, 50–52. 10.2337/db13-1606 - DOI - PubMed
Rai V., Maldonado A. Y., Burz D. S., Reverdatto S., Schmidt A. M., Shekhtman A. (2012). Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of c-terminal rage (ctRAGE) and its binding to mDia1. J. Biol. Chem. 287, 5133–5144. 10.1074/jbc.M111.277731 - DOI - PMC - PubMed
Reddy G. K. (2004). AGE-related cross-linking of collagen is associated with aortic wall matrix stiffness in the pathogenesis of drug-induced diabetes in rats. Microvasc. Res. 68, 132–142. 10.1016/j.mvr.2004.04.002 - DOI - PubMed
Reiniger N., Lau K., McCalla D., Eby B., Cheng B., Lu Y., et al. . (2010). Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. Diabetes 59, 2043–2054. 10.2337/db09-1766 - DOI - PMC - PubMed
Rubattu S., Mennuni S., Testa M., Mennuni M., Pierelli G., Pagliaro B., et al. . (2013). Pathogenesis of chronic cardiorenal syndrome: is there a role for oxidative stress? Int. J. Mol. Sci. 14, 23011–23032. 10.3390/ijms141123011 - DOI - PMC - PubMed
Sabbagh M. N., Agro A., Bell J., Aisen P. S., Schweizer E., Galasko D. (2011). PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 25, 206–212. 10.1097/WAD.0b013e318204b550 - DOI - PMC - PubMed
Safar M. E., Levy B. I., Struijker-Boudier H. (2003). Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation 107, 2864–2869. 10.1161/01.CIR.0000069826.36125.B4 - DOI - PubMed
Schleicher E. D., Wagner E., Nerlich A. G. (1997). Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J. Clin. Invest. 99, 457–468. 10.1172/JCI119180 - DOI - PMC - PubMed
Schmidt A. M., Yan S. D., Wautier J. L., Stern D. (1999). Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ. Res. 84, 489–497. 10.1161/01.RES.84.5.489 - DOI - PubMed
Sell D. R., Monnier V. M. (2012). Molecular basis of arterial stiffening: role of glycation - a mini-review. Gerontology 58, 227–237. 10.1159/000334668 - DOI - PubMed
Semba R. D., Sun K., Schwartz A. V., Varadhan R., Harris T. B., Satterfield S., et al. . (2015). Serum carboxymethyl-lysine, an advanced glycation end product, is associated with arterial stiffness in older adults. J. Hypertens. 33, 797–803; discussion: 803. 10.1097/HJH.0000000000000460 - DOI - PMC - PubMed
Sethi S., Rivera O., Oliveros R., Chilton R. (2014). Aortic stiffness: pathophysiology, clinical implications, and approach to treatment. Integr. Blood Press. Control 7, 29–34. 10.2147/IBPC.S59535 - DOI - PMC - PubMed
Sims T. J., Rasmussen L. M., Oxlund H., Bailey A. J. (1996). The role of glycation cross-links in diabetic vascular stiffening. Diabetologia 39, 946–951. 10.1007/BF00403914 - DOI - PubMed
Singh V. P., Bali A., Singh N., Jaggi A. S. (2014). Advanced glycation end products and diabetic complications. Korean J. Physiol. Pharmacol. 18, 1–14. 10.4196/kjpp.2014.18.1.1 - DOI - PMC - PubMed
Soulis T., Thallas V., Youssef S., Gilbert R. E., McWilliam B. G., Murray-McIntosh R. P., et al. . (1997). Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury. Diabetologia 40, 619–628. 10.1007/s001250050725 - DOI - PubMed
Spinetti G., Wang M., Monticone R., Zhang J., Zhao D., Lakatta E. G. (2004). Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler. Thromb. Vasc. Biol. 24, 1397–1402. 10.1161/01.ATV.0000134529.65173.08 - DOI - PubMed
Sprague A. H., Khalil R. A. (2009). Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem. Pharmacol. 78, 539–552. 10.1016/j.bcp.2009.04.029 - DOI - PMC - PubMed
Stitt A. W., He C., Friedman S., Scher L., Rossi P., Ong L., et al. . (1997). Elevated AGE-modified ApoB in sera of euglycemic, normolipidemic patients with atherosclerosis: relationship to tissue AGEs. Mol. Med. 3, 617–627. - PMC - PubMed
Strait J. B., Lakatta E. G. (2012). Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail. Clin. 8, 143–164. 10.1016/j.hfc.2011.08.011 - DOI - PMC - PubMed
Stürmer M., Šebeková K., Fazeli G., Bahner U., Stäb F., Heidland A. (2015). 25-hydroxyvitamin d and advanced glycation endproducts in healthy and hypertensive subjects: are there interactions? J. Ren. Nutr. 25, 209–216. 10.1053/j.jrn.2014.10.027 - DOI - PubMed
Takeuchi M., Makita Z., Yanagisawa K., Kameda Y., Koike T. (1999). Detection of noncarboxymethyllysine and carboxymethyllysine advanced glycation end products (AGE) in serum of diabetic patients. Mol. Med. 5, 393–405. - PMC - PubMed
Tan A. L., Forbes J. M., Cooper M. E. (2007). AGE, RAGE, and ROS in diabetic nephropathy. Semin. Nephrol. 27, 130–143. 10.1016/j.semnephrol.2007.01.006 - DOI - PubMed
Tanaka K., Tani Y., Asai J., Nemoto F., Kusano Y., Suzuki H., et al. . (2012). Skin autofluorescence is associated with severity of vascular complications in Japanese patients with type 2 diabetes. Diabet. Med. 29, 492–500. 10.1111/j.1464-5491.2011.03448.x - DOI - PubMed
Touré F., Fritz G., Li Q., Rai V., Daffu G., Zou Y. S., et al. . (2012). Formin mDia1 mediates vascular remodeling via integration of oxidative and signal transduction pathways. Circ. Res. 110, 1279–1293. 10.1161/CIRCRESAHA.111.262519 - DOI - PMC - PubMed
Uribarri J., del Castillo M. D., de la Maza M. P., Filip R., Gugliucci A., Luevano-Contreras C., et al. . (2015). Dietary advanced glycation end products and their role in health and disease. Adv. Nutr. 6, 461–473. 10.3945/an.115.008433 - DOI - PMC - PubMed
Vaitkevicius P. V., Lane M., Spurgeon H., Ingram D. K., Roth G. S., Egan J. J., et al. . (2001). A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc. Natl. Acad. Sci. U.S.A. 98, 1171–1175. 10.1073/pnas.98.3.1171 - DOI - PMC - PubMed
Vikramadithyan R. K., Hu Y., Noh H. L., Liang C. P., Hallam K., Tall A. R., et al. . (2005). Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. J. Clin. Invest. 115, 2434–2443. 10.1172/JCI24819 - DOI - PMC - PubMed
Wang M., Zhang J., Jiang L. Q., Spinetti G., Pintus G., Monticone R., et al. . (2007). Proinflammatory profile within the grossly normal aged human aortic wall. Hypertension 50, 219–227. 10.1161/HYPERTENSIONAHA.107.089409 - DOI - PubMed
Wautier J. L., Wautier M. P., Schmidt A. M., Anderson G. M., Hori O., Zoukourian C., et al. . (1994). Advanced Glycation End Products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications. Proc. Natl. Acad. Sci. U.S.A. 91, 7742–7746. 10.1073/pnas.91.16.7742 - DOI - PMC - PubMed
Wautier M. P., Chappey O., Corda S., Stern D. M., Schmidt A. M., Wautier J. L. (2001). Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am. J. Physiol. Endocrinol. Metab. 280, E685–E694. - PubMed
Wu M. S., Liang J. T., Lin Y. D., Wu E. T., Tseng Y. Z., Chang K. C. (2008). Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. Br. J. Pharmacol. 154, 758–764. 10.1038/bjp.2008.119 - DOI - PMC - PubMed
Xu B., Chibber R., Ruggiero D., Kohner E., Ritter J., Ferro A. (2003). Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products. FASEB J. 17, 1289–1291. 10.1096/fj.02-0490fje - DOI - PubMed
Xu Y., Toure F., Qu W., Lin L., Song F., Shen X., et al. . (2010). Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages. J. Biol. Chem. 285, 23233–23240. 10.1074/jbc.M110.117457 - DOI - PMC - PubMed
Xue J., Ray R., Singer D., Böhme D., Burz D. S., Rai V., et al. . (2014). The receptor for advanced glycation end products (RAGE) specifically recognizes methylglyoxal-derived AGEs. Biochemistry 53, 3327–3335. 10.1021/bi500046t - DOI - PMC - PubMed
Yamagishi S., Yonekura H., Yamamoto Y., Katsuno K., Sato F., Mita I., et al. . (1997). Advanced glycation end products-driven angiogenesis in vitro. Induction of the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor. J. Biol. Chem. 272, 8723–8730. 10.1074/jbc.272.13.8723 - DOI - PubMed
Yan S. D., Schmidt A. M., Anderson G. M., Zhang J., Brett J., Zou Y. S., et al. . (1994). Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J. Biol. Chem. 269, 9889–9897. - PubMed
Yan S. F., Ramasamy R., Naka Y., Schmidt A. M. (2003). Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ. Res. 93, 1159–1169. 10.1161/01.RES.0000103862.26506.3D - DOI - PubMed
Yonekura H., Yamamoto Y., Sakurai S., Petrova R. G., Abedin M. J., Li H., et al. . (2003). Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem. J. 370, 1097–1109. 10.1042/bj20021371 - DOI - PMC - PubMed
Zieman S. J., Melenovsky V., Clattenburg L., Corretti M. C., Capriotti A., Gerstenblith G., et al. . (2007). Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. J. Hypertens. 25, 577–583. 10.1097/HJH.0b013e328013e7dd - DOI - PubMed