Class 2. Study Guide
Topic:
Path 1. Nucleic acids: levels of DNA compactification. Methods for studying the structure and functions of nucleic acids.
Path 2. DNA replication and repair: mechanisms and biomedical significance. DNA structure damage and repair mechanisms. Medicine that inhibit replication.
Study questions:
- Levels of structural organization of chromatin. The role of histone and non-histone proteins in DNA compaction.
- Methods for studying the structure and functions of nucleic acids.
- DNA replication: basic principles of matrix biosynthesis. Consistency of replication and cell cycle.
- Initiation of DNA replication: the scheme of the process, the main enzymes and their function.
- Elongation and termination of DNA replication: the scheme of the process, the main enzymes and their function. Mechanisms of biosynthesis of leading and lagging DNA chains.
- Mechanisms of DNA structure damage and their biological consequences.
- DNA repair: the main mechanisms of DNA structure restoration. Violations of DNA repair systems and their biomedical significance.
- Medicine that inhibit replication.
Vocabulary (list of mandatory terms and concepts):
- nucleoside;
- nucleic acids;
- hydrogen bonding;
- biopolymers;
- Chargaff rule;
- histones;
- the nucleosome;
- euchromatin;
- heterochromatin;
- apurinization;
- interphase;
- replication origin;
- replicon;
- photolyase;
- DNA insertase;
- semi - conservativeness;
- replication fork;
- fragments of Okazaki;
- ligation;
- telomerase;
- Hayflick limit.
Последнее изменение: Вторник, 6 Сентябрь 2022, 20:16