Discipline "Molecular biology"

Topic:

Cell damage. Pathobiochemical aspects of necrosis. Types of programmed cell death. The role of apoptosis in norm and pathology.

Study questions:

1. Growth factors and mitogens: classification and mechanisms of action. Epidermal and transforming growth factor.
2. Growth factor receptors: structure and mechanisms of signal transduction.
3. The role of pro- and anti-apoptotic proteins in the regulation of the cell cycle. Cell cycle arrest after DNA damage.
4. Types and mechanisms of cell damage. Necrosis and apoptosis: definitions and comparative characteristics.
5. Types of programmed cell death. Apoptosis. Biological significance. Morphological signs of apoptosis. Comparative characteristics of necrosis and apoptosis.
6. Biochemical mechanisms of apoptosis: triggering factors, the role of caspases, cytochrome С, and protein p53.
7. Phases of apoptosis: classification of regulatory proteins and their functions. Formation by apoptosis.
8. Disorders of apoptosis. The role of apoptosis in the pathogenesis of tumor and neurodegenerative diseases.