Discipline "Molecular biology"

Regulation of gene expression in prokaryotes. The theory of the "operon". Mechanisms of gene induction and repression in eukaryotes. Medicines that modulate gene expression. Part 1, 2.

Study questions:

1. Features of gene expression in prokaryotes and eukaryotes.
2. Principles of regulation of gene expression in prokaryotes. The theory of the "operon". Lactose and tryptophan operon.
3. Levels of regulation of gene expression in eukaryotes. Packaging of genetic material.
4. Euchromatin and heterochromatin. Regulation of RNA transcription and processing.
5. Regulation of translation and post-translational modifications of the protein. Mechanisms of induction and repression of gene expression.

Vocabulary (list of mandatory terms and concepts):

• operon;
• promoter;
• enhancers;
• silencers;
• heterochromatin;
• exons;
• introns;
• repressor proteins
• alternative splicing;
• euchromatin;