Discipline "Molecular biology"

Topic:

Catalytic receptors. Molecular mechanisms of signal transduction from nuclear and cytoplasmic receptors. Regulation of receptor activity.

Study questions:

1. Catalytic receptors (Enzyme Linked Receptors).
2. The structure of nuclear receptors. Androgen/estrogen/glucocorticoid/mineralocorticoid/retinoid/thyroid hormone receptors.
3. Hormone sensitive DNA elements.
4. Mechanisms of hormonal induction of transcription and translation processes.
5. The interaction of hormones with the chromatin of target cells.
6. Activation of transcription by translocation of сAMP-dependent protein kinases from the cytoplasm into the nuclei of target cells.
7. Mechanisms of intracellular signal transduction and biological effects on the example of the insulin receptor.
8. Regulation of receptor activity.

Vocabulary (list of mandatory terms and concepts):